目的观察肝动脉化疗栓塞治疗对原发性肝癌的疗效及影响因素．方法单纯化疗（Ａ组）；化疗加碘油栓塞（Ｂ组）；化疗加碘油加明胶海绵栓塞（Ｃ组）．结果５年内肝动脉化疗栓塞治疗中、晚期肝癌４２８例，３８６例经２个月～５０个月随访．肿瘤缩小率：Ａ组１４％，Ｂ组５５％，Ｃ组７９％（三组间Ｐ＜００１）．肿瘤基本消失：Ｃ组５％，Ａ，Ｂ两组无１例消失．生存时间：１年生存率Ａ组０％，Ｂ组１０％，Ｃ组４５％，其中１２例患者获Ⅱ期手术切除，切除标本病理检查见肿瘤区癌细胞全部或部分凝固坏死，瘤旁癌细胞稀疏．结论影响疗效因素与肿瘤的病理类型及血供情况，门静脉主干瘘和癌栓、肝动脉插管治疗方式有关． Objective To observe the effect of hepatic arterial chemoembolization on primary liver cancer and its influencing factors. Methods chemotherapy alone (group A); chemotherapy plus lipiodol embolization (group B); chemotherapy plus lipiodol plus gelatin sponge embolization (group C). 5. Results Hepatic arterial chemoembolization was used to treat 428 cases of hepatocellular carcinoma in advanced and late stage within 5 years and 386 cases were followed up for 2 months to 50 months. Tumor reduction rate: 14% in group A, 55% in group B, and 79% in group C (P<001 between the three groups). The tumors basically disappeared: 5% in group C, and none disappeared in group A and B. Survival time: One-year survival rate was 0% in group A, 10% in group B, and 45% in group C. Among them, 12 patients had undergone stage II surgical resection. Excisional pathological examination showed that all or part of the cancer cells in the tumor area had coagulation and necrosis. Sparse cells. Conclusion The factors influencing the curative effect are related to the pathological type and blood supply of the tumor, the main portal vein spasm and the tumor emboli, and the treatment of hepatic artery catheterization.