血吸虫病是世界上一种严重的疾病,由寄生于肠管下段或膀胱有关血管的血吸虫成虫所致。此种寄生虫大多生存于这些免疫学上暴露的部位,因为血吸虫幼虫移居到那里时,从进入体内所经的皮肤获得了宿主那样的表面抗原。这种伪装非常有效,以致于完全不清楚,它对人体的免疫力有无任何影响。虽然用照射过的血吸虫幼虫制作的疫苗,是在苏丹和中国进行现场牲畜试验的成功基础,但在人体应用 Schistosomiasis is a serious disease in the world caused by adult worms that parasitize the lower intestine or bladder-related blood vessels. Most of these parasites live on these immunologically exposed sites, since the larvae of schistosome migrate there, gaining host-like surface antigens from the skin they penetrate into the body. This camouflage is so effective that it is completely unclear whether it has any effect on the body’s immunity. Although vaccines made from irradiated larvae of Schistosoma japonicum are a successful basis for field animal testing in Sudan and China,