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1.克林霉素的药代动力评价 虽然药代动力学数据对于给药剂量是至关重要的,但这一点不足以预期抗菌剂量。一个明了的药效动力学(例如抗菌浓度之间的关系和生物反应以及效应)是给药剂量最为基本的,抗生素的抗菌作用是以剂量反应曲线来说明的。举例来说,如果一个抗生素达到了50％和90％的静脉给药浓度,虽然理想的克林霉素血药浓度尚未确立,但维持血药浓度的给药间隔必须是使它在给药浓度50％以上,这是一个非浓度
1. Pharmacokinetic Evaluation of Clindamycin Although pharmacokinetic data is crucial for the dosage to be administered, it is not sufficient to anticipate the antibacterial dose. A clear pharmacodynamics (such as the relationship between antibacterial concentrations and the biological response and the effect) is the most basic dose, the antibacterial antibacterial effect is described by the dose response curve. For example, if an antibiotic achieves a 50% and 90% intravenous dose, although the ideal plasma clindamycin concentration has not been established, the dosing interval to maintain blood plasma concentration must be such that it will remain at the dosing concentration Above 50%, this is a non-concentration