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目的通过检测β1-肾上腺素能受体自身抗体,以探讨β受体阻滞剂治疗顽固性心衰患者对β1-肾上腺素能受体自身抗体、抗体滴度及心功能的影响。方法随机选取120例心力衰竭NYHA分级Ⅱ-Ⅲ级患者,分为两组,A组:比索洛尔首剂1.25mg qd,每两周逐渐加量,直至10mg qd;B组:比索洛尔首剂1.25mg qd,4周后逐渐加至5mgqd。比较两组β1-肾上腺素能受体自身抗体及心功能各项指标的变化。结果 A组β1-肾上腺素能受体自身抗体及滴度较B组明显降低,心功能各项指标有改善的趋势。结论通过检测β1-肾上腺素能受体自身抗体,发现比索洛尔剂量的增加使β1-肾上腺素能受体自身抗体阳性率及抗体滴度明显降低,并改善了顽固性心力衰竭患者的心功能。
Objective To investigate the effects of β1-adrenergic receptor autoantibodies on β1-adrenergic receptor autoantibodies, antibody titers and cardiac function in patients with refractory heart failure treated with β-blocker. Methods A total of 120 NYHA class Ⅱ-Ⅲ patients with heart failure were randomly divided into two groups: group A: bisoprolol first dose 1.25 mg qd, every two weeks gradually increasing until 10 mg qd; group B: bisoprolol 1.25 mg qd dose, gradually added after 4 weeks 5mgqd. The changes of β1-adrenergic receptor autoantibodies and cardiac function in the two groups were compared. Results The autoantibodies and titers of β1-adrenergic receptor in group A were significantly lower than those in group B, and the indexes of cardiac function showed an improving trend. Conclusion By detecting the β1-adrenergic receptor autoantibodies, it was found that increased doses of bisoprolol resulted in a significant decrease in the autoantibodies and antibody titers of β1-adrenergic receptors and improved cardiac function in patients with refractory heart failure .