许多实验研究表明,通过三种不同类型的机理,病毒可与肾小球疾病的发病有关。第一,病毒对肾小球细胞可有直接的致病作用。第二,肾脏损伤可能由于宿主反应,例如,病毒抗原可能诱发免疫反应,导致形成循环内免疫复合物(IC),沉淀于肾小球。此外,宿主对病毒感染的另一些反应亦可起作用。例如干扰素,可触发或加剧某些类型的肾小球肾炎(GN)。第三,病毒有可能与某一些伴有GN的自身免疫疾病 Many experimental studies have shown that the virus can be associated with the pathogenesis of glomerular diseases through three different types of mechanisms. First, the virus can have a direct pathogenic role in glomerular cells. Second, kidney damage may be due to host reactions. For example, viral antigens may induce an immune response, resulting in the formation of circulating immunocomplexes (ICs) that precipitate in the glomerulus. In addition, other host responses to viral infections may also work. Such as interferon, can trigger or exacerbate certain types of glomerulonephritis (GN). Third, the virus may be associated with certain autoimmune diseases with GN