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目的探讨类风湿关节炎(RA)与肿瘤坏死因子诱导蛋白3(TNFAIP3)基因多态性的关联性。方法选择TNFAIP3基因6个位点(rs6920220、rs2230926、rs5029937、rs10499194、rs2327832、rs13207033),检索已发表的RA与TNFAIP3基因多态性关联研究的文献进行Meta分析。结果 18篇文献共纳入27554例RA患者和39 664例正常对照。综合分析显示,TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联(P<0.01,P=0.03,P=0.002);TNFAIP3基因rs2327832和rs13207033位点基因多态性与RA无关联(P=0.27,P=0.05)。亚组分析显示,白种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=0.87(0.80~0.95),P<0.01];黄种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=1.28(1.13~1.46),P<0.01]。结论 Meta分析显示,TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联,rs10499194位点基因多态性与RA的关联有种族差异。
Objective To investigate the association between rheumatoid arthritis (RA) and tumor necrosis factor-inducible protein 3 (TNFAIP3) gene polymorphism. Methods The 6 sites of TNFAIP3 gene (rs6920220, rs2230926, rs5029937, rs10499194, rs2327832, rs13207033) were selected to search the published literature about the association between RA and TNFAIP3 gene polymorphisms for Meta-analysis. Results A total of 18 554 RA patients and 39 664 normal controls were included in the 18 articles. Comprehensive analysis showed that the polymorphisms of rs6920220, rs2230926 and rs5029937 in TNFAIP3 gene were associated with RA (P <0.01, P = 0.03, P = 0.002). The polymorphisms of rs2327832 and rs13207033 in TNFAIP3 gene were not associated with RA (P = 0.27, P = 0.05). A subgroup analysis showed that there was association between gene polymorphism of rs10499194 in TNFAIP3 gene and RA (OR = 0.87 (0.80-0.95), P <0.01]; rs10499194 polymorphism of yellow human TNFAIP3 gene was associated with RA Correlation [OR = 1.28 (1.13-1.46), P <0.01]. Conclusions Meta-analysis showed that the polymorphisms of rs6920220, rs2230926 and rs5029937 in TNFAIP3 gene were associated with RA, and the association of rs10499194 gene polymorphism and RA with racial differences.