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厌氧菌成为慢性化脓性中耳炎的重要病原菌原已明确。其中脆弱类杆菌属(bacteroides fragilis)较常见,消化球菌属(peptococcus)和丙酸杆菌属(propionibact erium)亦偶见。在慢性化脓性中耳炎并发脑脓肿病例中,脆弱类杆菌的感染较普遍,且治疗比较困难。本文用脆弱类杆菌属诱发豚鼠中耳炎模型,观察灭滴灵的治疗效果。用白色的豚鼠59只,仔细消毒外耳道,以0.5～1.0~8脆弱类杆菌经鼓膜注入右侧中耳腔内。所有豚鼠每天经腹膜注射庆大霉素4.5 mg,预防厌氧菌的移地发育(colonization)和重复感染(superinfection),连续14天。7天后开始用灭滴灵治疗,共分四组:1组17只,不予治疗。2组17只,注射灭滴灵6mg(20m g/kg),每天一次。3组10只,注射6mg,每天两次。4组14只,注射15mg(50mg/kg),每天一次。到14天
Anaerobic bacteria has become an important pathogen of chronic suppurative otitis media has been clear. Among them, bacteroides fragilis is more common, and peptococcus and propionibact erium are also occasionally seen. In cases of chronic suppurative otitis media with cerebral abscess, Bacteroides fragilis infection is more common and the treatment is more difficult. In this paper, brittle genus Bacteroides induced otitis media model in guinea pigs to observe the therapeutic effect of metronidazole. 59 white guinea pigs, carefully disinfect the external auditory meatus to 0.5 ~ 1.0 ~ 8 Bacteroides fragilis by the tympanic membrane into the right middle ear cavity. All guinea pigs were given an intraperitoneal injection of gentamicin 4.5 mg daily, preventing colonization and superinfection of anaerobic bacteria for 14 consecutive days. 7 days after the start of metronidazole treatment, is divided into four groups: a group of 17, no treatment. Two groups of 17, injection of metronidazole 6mg (20m g / kg), once daily. 3 groups of 10, injection 6mg, twice daily. Four groups of 14, injection of 15mg (50mg / kg) once a day. To 14 days