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目的分析比较吡柔比星(吡喃阿霉素,THP)与盐酸阿霉素(ADM)治疗老年非霍奇金淋巴瘤(NHL)的疗效与不良反应。方法将116例老年(≥50岁)MHL患者随机分成两组,第一组59例,选用THP联合化疗;第二组57例,选用ADM联合化疗,3个疗程后判断疗效及不良反应,进行统计分析。结果含THP化疗组总有效率84.7%,心脏毒性8.5%,脱发率17.0%;含ADM化疗组总有效率75.6%,心脏毒性15.8%,脱发率70.2%。骨髓抑制两者无明显差异。结论THP疗效高于ADM,而且不良反应低,尤其心脏毒性较低,故THP较适合用于老年NHL患者。
Objective To compare the efficacy and side effects of pirarubicin (THP) and doxorubicin hydrochloride (ADM) in the treatment of elderly non-Hodgkin’s lymphoma (NHL). Methods One hundred and sixty-one elderly patients (≥50 years old) with MHL were randomly divided into two groups. The first group consisted of 59 patients with THP combined with chemotherapy. The second group (57 patients) received ADM combined with chemotherapy. After three courses of treatment, the efficacy and adverse reactions were evaluated Statistical Analysis. Results The total effective rate of THP group was 84.7%, the cardiotoxicity was 8.5% and the rate of hair loss was 17.0%. The total effective rate of ADM group was 75.6%, cardiotoxicity was 15.8% and hair loss rate was 70.2%. There was no significant difference between the two groups in myelosuppression. Conclusions THP is more effective than ADM in treating rheumatoid arthritis, and its adverse reaction is low, especially its cardiotoxicity is low. Therefore, THP is more suitable for elderly patients with NHL.