mda 7/IL 2 4是在黑色素瘤细胞中发现的一个与黑色素瘤分化相关的基因 ,位于染色体 1q3 2 .2～ 1q41区域。编码蛋白MDA 7/IL 2 4通过与受体IL 2 0R1,IL 2 2R1与IL 2 0R2形成的 2种异二聚体复合物结合进行信号转导 ,对多种组织起源的肿瘤细胞均有抑制作用 ,还能在IFN β和分化诱导剂MEZ的作用下间接诱导黑素瘤细胞向终末期分化 ,但对正常细胞并无明显的毒副作用 ,在肿瘤的基因治疗上具有应用前景 mda 7 / IL 2 4 is a gene associated with melanoma differentiation found in melanoma cells, located on the chromosome 1q3 2 .2 ~ 1q41 region. The encoded protein MDA 7 / IL 2 4 is involved in signal transduction by binding to two heterodimeric complexes formed by the receptors IL20R1, IL22R1 and IL20R2 and inhibits tumor cells of various tissue origins But also induces the differentiation of melanoma cells to the terminal stage indirectly under the action of IFN β and the differentiation inducer MEZ, but has no obvious toxic and side effects on normal cells, and has the application prospect in gene therapy of tumors