论文部分内容阅读
Objective:The aim of this study was to study the short-term curative effects and adverse reactions of docetaxel(DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu(DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma.Methods:Thirty-three patients in the experimental group(DOC group) were given DOC 25 mg/m 2 ivgtt,d1,7 times,concurrent radiotherapy was performed from d1.Thirty-three patients in the control group(DF group) were given cisplatin 25 mg/m 2 ivgtt d1–3 and 5-Fu 550 mg/m 2 iv,d1–5,3 weeks a cycle,2 cycles,and concurrent radiotherapy was performed from d1.Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concurrent radiotherapy.Results:The response rates of DOC group and DF group were 90.9% and 93.9%,the rates of neutropenia were 45.45% and 67.74%,and the rates of oral mucositis were 60.61% and 90.32%.Conclusion:The difference of shortterm curative effects between DOC group and DF group was not statistically significant in patients with advanced nasopharyngeal carcinoma.The rates of adverse reactions were lower in DOC group.DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma.
Objective: The aim of this study was to study short-term curative effects and adverse reactions of docetaxel (DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu (DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma. Methods: Thirty-three patients in the experimental group (DOC group) were given DOC 25 mg / m 2 ivgtt, d1,7 times, concurrent radiotherapy was performed from d1.Thirty-three patients in the control group (DF group) were given cisplatin 25 mg / m2 ivgtt d1-3 and 5-Fu 550 mg / m2 iv, d1-5, 3 weeks a cycle, 2 cycles, and concurrent radiotherapy was performed from d1.Six MV X-ray and 9 MeV electronic line for Results: The response rates of DOC and DF groups were 90.9% and 93.9%, the rates of neutropenia were 45.45% and 67.74% respectively, and the rates of oral mucositis were 60.61% and 90.32%. Conclusion: The difference of short term curative effects between DOC group and DF group was not statistically significantly in patients with advanced nasopharyngeal carcinoma. The rates of adverse reactions were lower in DOC group. DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma.