论文部分内容阅读
目的研究具有生物降解特性的镁合金覆膜支架对于兔颈内动脉动脉瘤治疗的可行性。方法利用40只新西兰大白兔建立颈内动脉动脉瘤模型,分别使用Willis覆膜支架和镁合金覆膜支架植入对实验兔进行治疗。定期对植入支架的实验兔进行血管造影检查和钼靶检查,观察植入支架后动脉瘤的情况、颈内动脉的情况和支架的降解程度。结果所有大白兔造模成功,20只大白兔植入了Willis覆膜支架,20只大白兔植入了镁合金覆膜支架。血管造影检查结果显示,植入支架后40只大白兔的动脉瘤均显示为腔闭塞状态,且动脉瘤所处的颈内动脉通畅;3个月后植入镁合金覆膜支架的20只大白兔的动脉瘤均显示为腔闭塞状态且颈内动脉通畅,而植入Willis覆膜支架的19只正常,1只大白兔颈内动脉呈现出闭塞状态;植入1年后19只大白兔动脉瘤治愈,1只大白兔的颈内动脉闭塞未完全痊愈。钼靶检查结果显示镁合金覆膜支架具有生物降解的特性,随着时间的延长而降解,而Willis覆膜支架并不随着时间延长而降解。结论具有生物降解特性的镁合金覆膜支架治疗兔颈内动脉动脉瘤较传统治疗方式具有更好的疗效。
Objective To study the feasibility of biomedical coated magnesium alloy stent for the treatment of internal carotid artery aneurysm in rabbits. Methods 40 New Zealand white rabbits were used to establish the model of internal carotid artery aneurysm. The Willis-covered and magnesium-coated stents were used to treat rabbits. The rabbits implanted with stent were regularly examined by angiography and mammography. The aneurysm after stent implantation, the situation of internal carotid artery and the degree of stent degradation were observed. Results All rabbits were successful in modeling. Willis stent was implanted in 20 rabbits and magnesium alloy stent was implanted in 20 rabbits. Angiography showed that the aneurysms of the 40 rabbits after implantation of the stent all showed lumen occlusion, and the internal carotid artery in which the aneurysm was located was smooth. Twenty of the white-coated magnesium alloy stents were implanted 3 months later The rabbit aneurysms showed lumen occlusion and the internal carotid artery was unobstructed. However, 19 normal and 1 rabbit white rabbits with Willis stent were occluded. One rabbit 19 years after implantation Tumor cured, a white rabbit internal carotid artery occlusion is not fully recovered. Molybdenum target examination revealed biodegradable magnesium alloy coated stents that degrade over time, whereas Willis coated stents did not degrade over time. Conclusion Magnesium alloy covered scaffold with biodegradable characteristics has better curative effect than the traditional treatment of internal carotid artery aneurysm in rabbits.