论文部分内容阅读
目的探讨宫颈上皮内瘤变(CIN)的最佳诊断及其对治疗的影响。方法对2006年在我院诊断为CIN的45例患者的宫颈液基细胞学,高危HPV检测,术前宫颈多点活检,宫颈锥切(包括传统锥切和LEEP刀切除)病理诊断,术后组织学结果及治疗方法等资料进行回顾性分析。结果细胞学检查存在假阴性率约2.22%(1/45),低度宫颈上皮内瘤变(CINI)约77%(7/9)为高危HPV阳性,高度宫颈上皮内瘤变(CINII、III)约92%(25/27)为高危HPV阳性,术前宫颈多点活检的过低诊断率为20%,漏诊浸润癌5例,宫颈锥切病理诊断后过低诊断率降至0%,无浸润癌漏诊。结论经宫颈细胞学结合高危型HPV检测的筛查指导阴道镜下多点活检可以提高诊断准确性,宫颈锥切病理诊断中减少对宫颈癌及CIN的过低诊断,有利于选择合理的治疗方法。
Objective To investigate the best diagnosis of cervical intraepithelial neoplasia (CIN) and its effect on treatment. Methods Cervical liquid-based cytology, high-risk HPV testing, preoperative cervix multipoint biopsy, conization of the cervix (including conventional conization and LEEP excision) were performed in 45 patients with CIN diagnosed in our hospital in 2006. Histological findings and treatment methods and other data for retrospective analysis. Results Cytological examination showed a false-negative rate of about 2.22% (1/45), low-grade cervical intraepithelial neoplasia (CINI) of about 77% (7/9), high-risk HPV positive and high grade cervical intraepithelial neoplasia ) About 92% (25/27) were high-risk HPV-positive, preoperative cervix multi-point biopsy was 20% low diagnosis, missed diagnosis of invasive carcinoma in 5 cases, cervical conization pathological diagnosis of low diagnostic rate dropped to 0% No invasive cancer missed diagnosis. Conclusion Cervical cytology combined with high-risk HPV screening screening guide multi-point colposcopy biopsy can improve the diagnostic accuracy of cervical conization pathological diagnosis of cervical cancer and CIN to reduce the low diagnosis is conducive to the selection of a reasonable treatment .