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目的探讨房颤患者左房内径(LAD)与血栓前状态指标相关性及临床意义。方法对我院60例房颤患者及对照组无房颤患者20例进行观察,M型心脏超声测定LAD,同时检测其血浆假性血友病因子(vwF)、D-二聚体(D-D)及纤维蛋白原(Fg)浓度。结果房颤患者LAD≥40mm组较LAD<40mm组的vwF、D-D及Fg浓度显著增加(分别为P<0.001、P<0.001、P<0.01);病例组显著高于对照组(均P<0.001)。LAD大小与vwF、D-D及Fg呈显著正相关,LAD与vwF、D-D的相关性较大(r=0.83,P<0.01;r=0.72,P<0.01),LAD与Fg的相关性较小(r=0.53,P<0.01),两组相比差异均有统计学意义(P<0.05)。结论房颤患者存在血栓前状态,且房颤患者LAD越大则血液凝固性越高,发生血栓的可能性越大。
Objective To investigate the correlation between the left atrium diameter (LAD) and pre-thrombotic parameters in patients with atrial fibrillation and its clinical significance. Methods Twenty patients with atrial fibrillation (AF) and control group without AF were observed in our hospital. MAD was used to measure LAD and the plasma levels of vWF, DD, And fibrinogen (Fg) concentrations. Results The concentrations of vwF, DD and Fg in LAD≥40mm group were significantly higher than those in LAD40mm group (P <0.001, P <0.001, P <0.01, respectively) ). There was a significant positive correlation between LAD and vwF, DD and Fg, LAD and vwF and DD (r = 0.83, P <0.01; r = 0.72, P <0.01) r = 0.53, P <0.01), the differences between the two groups were statistically significant (P <0.05). Conclusion There is prethrombotic state in patients with atrial fibrillation, and the greater the LAD in patients with atrial fibrillation, the higher the blood coagulation, the greater the possibility of thrombosis.