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目的:比较主动脉旁反搏装置(paraaortic counterpulsation device,PACD)与主动脉内球囊反搏装置(IABP)对急性心衰动物模型的辅助效果。方法:成年小尾寒羊8只,体重(44.6±3.9)kg。将PACD吻合于降主动脉,同时经股动脉植入IABP,分别连接至IABP控制台,PACD及IABP均依靠体表心电图触发。结扎冠脉分支建立急性心衰动物模型,采集PACD及IABP反搏前后血流动力学指标变化。结果:IABP及PACD辅助后,心输出量分别增加了11.97%、13.83%(P>0.05)。主动脉舒张末压分别下降了4.3%、9.68%(P<0.05)。主动脉平均舒张压分别增加了10.46%、19.47%(P<0.05)。左颈动脉血流量分别增加10.43%、20.03%(P<0.05)。结论:PACD及IABP对急性心衰羊均有辅助作用,但PACD更显著降低了左室后负荷,增加了心肌、脑的灌注,是一种更有效的反博辅助装置。
Objective: To compare the effects of paraaortic counterpulsation device (PACD) and intra-aortic balloon pump (IABP) on acute heart failure animal model. Methods: 8 small tail sheep, weighing 44.6 ± 3.9 kg. PACD anastomosis to the descending aorta, while the femoral artery implanted IABP, were connected to the IABP console, PACD and IABP are relied on the body surface ECG trigger. The animal model of acute heart failure was established by ligation of coronary artery branches and the changes of hemodynamics before and after PACD and IABP counterpulsation were collected. Results: After IABP and PACD assisted, cardiac output increased by 11.97% and 13.83%, respectively (P> 0.05). Aortic end-diastolic pressure decreased by 4.3%, 9.68% (P <0.05). The average aortic diastolic pressure increased by 10.46%, 19.47% (P <0.05). Left carotid artery blood flow increased by 10.43%, 20.03% (P <0.05). CONCLUSION: Both PACD and IABP have auxiliary effects on acute heart failure, but PACD can significantly reduce left ventricular afterload and increase myocardial and cerebral perfusion, which is a more effective anti-Bo auxiliary device.