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目的观察对比持续静脉微量注射呋塞米对严重充血性心力衰竭(CHF)患者疗效是否优于传统的间断注射疗效。方法在常规防重构、强心、扩血管的基础上,观察分析72例NYHA心功能Ⅲ-Ⅳ级患者,分为持续静脉微量注射呋塞米组(观察组)35例和间断注射呋塞米组(对照组)37例,两组使用呋塞米剂量大致相同,比较两组治疗前后尿量、血压波动、血液电解质浓度、超声心动图心功能指标、症状缓解时间和水肿消退时间的差别。结果观察组治疗后尿量多于对照组,心功能指标FS和LVEF改善显著优于对照组,症状缓解时间和水肿消退时间短于对照组(P<0.01或0.05);血压和血液电解质浓度无显著差异(P>0.05)。结论持续静脉微量注射呋塞米治疗严重CHF,疗效明显优于传统的间断静脉注射法。
Objective To observe whether the efficacy of continuous intravenous furosemide in patients with severe congestive heart failure (CHF) is better than that of traditional intermittent injections. Methods 72 patients with NYHA cardiac function Ⅲ-Ⅳ grade were observed and analyzed on the basis of routine anti-remodeling, cardioplegia and vasodilatation. They were divided into continuous venous microinjection of furosemide (observation group), 35 cases and intermittent injection of furosemide (Control group). The dosage of furosemide in both groups was about the same. Before and after treatment, the urine volume, blood pressure fluctuation, blood electrolyte concentration, echocardiographic cardiac function, symptom relief time and edema subsidence time were compared . Results After treatment, the urine output of the observation group was more than that of the control group. The improvement of heart function index (FS) and LVEF was significantly better than that of the control group. The duration of symptom relief and edema disappearance were shorter than those of the control group (P <0.01 or 0.05). Blood pressure and blood electrolyte concentration Significant difference (P> 0.05). Conclusion Continuous intravenous microinjection of furosemide in the treatment of severe CHF is obviously better than the traditional intermittent intravenous injection.