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目的 :中药华蟾素和岩舒注射液作为全身治疗和 10 -羟基喜树碱膀胱灌注预防和治疗肿瘤复发。方法 :2 4例膀胱肿瘤患者经尿道汽化电切后 ,给予华蟾素 2 0mL和岩舒 2 0mL每日交替使用 ,并采用 10 -羟基喜树碱2 0mg +生理盐水 10 0mL膀胱灌注。治疗 2年预防肿瘤复发。结果 :随访期 18～ 36个月 ,平均 2 5 .71月 ,共计 2 4例术后治疗 18月无肿瘤复发 ,2 4月后膀胱肿瘤复发 1例 ,占 4 .16 %。结论 :中西医结合治疗方法疗效较好 ,中药和 10-羟基喜树碱无全身性化疗的毒副反应发生。
OBJECTIVE: To investigate the effect of cinobufacini and yanshu injection on the prevention and treatment of tumor recurrence as a systemic therapy and intravesical instillation of 10 - hydroxycamptothecin. Methods: Twenty - four cases of bladder cancer were transurethral resection of the urethra. The rats were given alternated with 20 mL of cinobufacini and 20 mL of Yan Shu daily by intravesical instillation of 10 - hydroxycamptothecin 20 mg and normal saline 10 0 mL. Treatment for 2 years to prevent tumor recurrence. Results: The follow-up period was 18-36 months (mean 25.57 months). A total of 24 cases had no recurrence after 18 months of treatment and 1 case had recurrent bladder tumor after 24 months (4.16%). Conclusion: The combination of traditional Chinese and western medicine has a good curative effect. The side effects of traditional Chinese medicine and 10-hydroxycamptothecin without systemic chemotherapy occur.