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目的:研究TGF-β1(转化生长因子-β1)、HIF-1α(低氧诱导因子-1α)、VEGF(血管内皮生长因子)在胃癌组织及癌旁组织中的表达及临床意义。方法:选取于我院就诊的160例胃癌手术患者切除的组织,采用免疫组化技术检测手术切除的胃癌组织中的TGF-β1、HIF-1α及VEGF的表达,分析其与患者临床病理参数的关系。结果:免疫组化结果显示:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达均高于癌旁组织,差异均有统计学意义(P<0.05);TGF-β1、HIF-1α及VEGF的表达均与肿瘤分期、淋巴结转移及浸润深度有关(P<0.05);VEGF的表达分别与TGF-β1、HIF-1α的表达呈相关关系(P<0.05)。结论:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达与胃癌的病理学特征有关,检测TGF-β1、HIF-1α及VEGF的表达将有助于临床诊治胃癌患者。
Objective: To study the expression and clinical significance of TGF-β1, HIF-1α and VEGF in gastric cancer tissue and paracancerous tissues. Methods: The resected tissues from 160 patients with gastric cancer who were treated in our hospital were selected. The expression of TGF-β1, HIF-1α and VEGF in the resected gastric cancer tissues were detected by immunohistochemistry. relationship. Results: The results of immunohistochemistry showed that the expressions of TGF-β1, HIF-1α and VEGF in gastric cancer tissues were significantly higher than those in paracancerous tissues (P <0.05). The expressions of TGF-β1, HIF- The expression of VEGF was correlated with tumor stage, lymph node metastasis and depth of invasion (P <0.05). The expression of VEGF was correlated with the expression of TGF-β1 and HIF-1α (P <0.05). Conclusion: The expression of TGF-β1, HIF-1α and VEGF in gastric cancer is related to the pathological features of gastric cancer. Detecting the expression of TGF-β1, HIF-1α and VEGF will be helpful for clinical diagnosis and treatment of gastric cancer.