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目的 研究传统的中枢性抗高血压药可乐定对常见有机磷农药中毒保护作用。方法 应用正交实验设计原理 ,选用L9(34)正交表 ,分别测试阿托品和可乐定对 5种常见有机磷农药乐果、敌百虫、马拉硫磷、敌敌畏、甲胺磷染毒小鼠的身体震颤出现的时间、翻正反射消失的时间和存活时间的影响。结果 小鼠生存时间随有机磷农药染毒剂量的增加而缩短 ,有明显的剂量 效应关系。染毒前给予阿托品、可乐定明显延长小鼠的生存时间 ,以及延长小鼠中毒症状出现的时间。有机磷农药染毒后给予阿托品、可乐定 ,小鼠生存时间延长与否因农药而异 ,与其中毒作用迅速程度有关。结论 可乐定对有机磷农药中毒有较强的对抗作用 ,及早用药可显著延长中毒小鼠的生存时间。鉴于老药新用及与阿托品不同的作用机制 ,在正确掌握指征及剂量情况下 ,完全可以在临床上使用
Objective To study the protective effect of traditional central antihypertensive drug clonidine on common organophosphorus pesticide poisoning. Methods Orthogonal experimental design principle was used. The orthogonal test was used to test the effects of atropine and clonidine on five kinds of common organophosphorus pesticide dimethoate, trichlorfon, malathion, dichlorvos and methamidophos The time it takes for the rat’s body tremor to appear, the time that the right reflex disappears, and the effect of survival time. Results The survival time of mice was shortened with the increase of organophosphate pesticide exposure dose, showing a significant dose-response relationship. Pretreatment given atropine, clonidine significantly prolong the survival time of mice, as well as prolonged poisoning symptoms appear in mice. Organophosphorus pesticides given to atropine after exposure, clonidine, mouse survival time or not due to different pesticides, and its toxic effects on the rapid extent. Conclusion Clonidine has a strong antagonistic effect on organophosphorus pesticide poisoning, and early administration can significantly prolong the survival time of poisoned mice. In view of the new drug and old and atropine different mechanism of action, in the proper grasp of indications and dosage cases, can be completely used in clinical