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目的:研究右旋酮洛芬缓释胶囊制备的处方条件。方法:采用喷雾干燥法制备右旋酮洛芬缓释细粒,填充入胶囊制成缓释胶囊,测定缓释胶囊(或细粒)的体外释放度,并考察制备处方条件对药物释放度的影响。结果:喷雾干燥法制备右旋酮洛芬缓释细粒,填充入胶囊即为缓释胶囊;在最优处方条件下缓释胶囊1h内体外累计释药量不超过30%,24h不低于90%。结论:该处方条件的右旋酮洛芬缓释胶囊的生产工艺简单可行,最终所得的缓释胶囊具有较好的缓释特征。
Objective: To study the prescription of dexketoprofen sustained release capsules. Methods: The dexketoprofen sustained-release granules were prepared by spray-drying method and filled into capsules to make sustained release capsules. The in vitro release of sustained-release capsules (or granules) was measured and the release of dexketoprofen influences. Results: The dexketoprofen sustained-release granules were prepared by spray-drying, and the capsules were filled into the sustained-release capsules. The cumulative release in vitro and in vivo in the optimal formulation was less than 30% 90%. CONCLUSION: The production process of dexketoprofen sustained release capsules under this prescription condition is simple and feasible. The sustained release capsules finally obtained have better sustained release characteristics.