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目的:分析Fas介导细胞凋亡的可能机制,探讨运动与Fas介导心肌、骨骼肌、淋巴细胞凋亡的关系,从新的认识层次解释运动训练状态下组织细胞损伤的变化,对过度训练的预防与治疗提供科学的理论依据。资料来源:采用计算机检索springlinker,pubmed数据库1994-01/2004-12Fas介导骨骼肌、心肌、淋巴细胞凋亡的相关文章,检索词为“Fas,apoptosis,exercise,skeletalmuscle,cardiomyocyte,lymphocyte”,并限定文章的语种类为“English”。同时利用计算机检索中国期刊全文数据库1994-01/2004-12的相关文章,限定文章语言种类为中文,检索词“运动,细胞凋亡,骨骼肌,心肌,淋巴细胞”。资料选择:对资料进行初审,纳入标准:关于Fas介导心肌、骨骼肌、淋巴细胞凋亡的研究。排除标准:排除重复性研究。资料提炼:共收集到符合上述要求的文献58篇,排除29篇重复性研究,29篇符合纳入标准。资料综合:细胞凋亡是一种由基因控制的细胞自主性死亡过程,其性质为生理性细胞死亡,Fas作为诱发细胞凋亡的死亡因子,在调控细胞凋亡中有着重要的生物学意义。对运动与Fas介导细胞凋亡信号传导机制的研究,将会从新的认识层次解释运动训练状态下组织细胞损伤的变化,对过度训练的预防与治疗提供科学的理论依据。此外,Fas在许多肿瘤、免疫系统疾病、脊髓损伤中起重要作用。结论:对运动与Fas介导凋亡的深层次研究,可能会揭示治疗疾病的机制带来新的运动治疗方法,对促进人类健康无疑有重要实际意义。
OBJECTIVE: To analyze the possible mechanism of Fas-mediated apoptosis, to explore the relationship between exercise and Fas-mediated apoptosis of myocardium, skeletal muscle and lymphocyte, to explain the change of tissue injury under exercise training from a new level of cognition, Prevention and treatment provide a scientific theoretical basis. Source: The articles related to apoptosis induced by skeletal muscle, myocardium and lymphocyte were searched by springlinker and pubmed database from January 1994 to December 2004 with the search term of “Fas, apoptosis, exercise, skeletalmuscle, cardiomyocyte, lymphocyte” The article type is “English”. At the same time, computer search Chinese Journal Full-text Database 1994-01 / 2004-12 related articles, limited article language for the Chinese, search term "exercise, apoptosis, skeletal muscle, myocardium, lymphocytes. Data Selection: Preliminary review of data, inclusion criteria: on Fas-mediated apoptosis in cardiac muscle, skeletal muscle and lymphocytes. Exclusion Criteria: Eliminate repetitive studies. Data Extraction: A total of 58 articles meeting the above requirements were collected, excluding 29 repetitive studies and 29 articles meeting the inclusion criteria. DATA SYNTHESIS: Apoptosis is a gene-controlled process of autophagic cell death, which is characterized by physiological cell death. Fas, as a death factor inducing apoptosis, has important biological significance in the regulation of apoptosis. The research on the mechanism of signal transduction mediated by Fas and Fas movement will explain the change of cell injury under exercise training state from a new level of cognition and provide a scientific theoretical basis for the prevention and treatment of over training. In addition, Fas plays an important role in many tumors, immune system diseases and spinal cord injury. CONCLUSIONS: In-depth studies of exercise and Fas-mediated apoptosis may reveal a new therapeutic approach to disease management that undoubtedly has important practical implications for human health.