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1986年6月,作者对扎伊尔金沙萨玛玛耶姆医院收治的33例确诊为恶性疟的儿童成功地进行了氯喹、奎宁和乙胺嘧啶的48小时体外敏感性测定。测试对象年龄1～12岁(平均5岁),初始原虫率在0.3～39％,3例为脑型疟,9例原虫率高于10％。到医院就诊前两周有21名患儿服过已知的抗疟药:其中服过氯喹者18例,服过奎宁者1例,服过氯喹加奎宁者2例。所有病例都在静脉采血后6小时内测试。感染的血样本用含RPMI 1640,30mM HE PES缓冲液及10％AB型无免疫力的人血清
In June 1986, the authors successfully tested the 48-hour in vitro susceptibility of chloroquine, quinine and pyrimethamine to 33 children diagnosed with falciparum malaria who were admitted to the Kinshasa Mamayej Hospital in Zaire. Subjects aged 1 to 12 years (mean age 5 years), the initial protozoan rate of 0.3 to 39%, 3 cases of cerebral malaria, 9 cases of protozoa higher than 10%. Twenty-two children had taken the known antimalarial drugs two weeks before going to the hospital for treatment: 18 were given chloroquine, one was taken with quinine, and two were given chloroquine and quinine. All cases were tested within 6 hours after venous blood sampling. Infected blood samples were stained with RPMI 1640, 30 mM HE PES buffer and 10% AB non-immune human serum