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目的研究甲亢患者甲状腺激素水平与骨代谢指标变化关系。方法选取深圳市第二人民医院2015年1月-2016年6月接收的53例甲状腺功能亢进症患者为甲亢组,另选45例健康体检者为对照组。采用电化学分析法及酶联免疫吸附法(ELISA)对所有研究对象甲状腺激素进行检测同时采用SGY-Ⅱ双能量X射线骨密度仪测定骨密度。比较两组甲状腺激素水平及骨代谢指标,并采用Spearman分析相关性。结果甲亢组T_3、T_4、FT_3、FT_4、TSH、NBAP、CT水平显著高于对照组差异有统计学意义(P<0.05),观察组BMD水平显著低于对照组差异有统计学意义(P<0.05)。两组T_3、T_4、FT_3、FT_4、TSH与NBAP、CT呈正相关,与BMD呈负相关差异有统计学意义(P<0.05)。结论甲亢患者甲状腺激素水平异常会导致骨吸收与骨代谢紊乱,出现骨密度下降,应及早干预,避免骨质疏松的发生。
Objective To study the relationship between thyroid hormone levels and the changes of bone metabolism index in patients with hyperthyroidism. Methods Fifty-three patients with hyperthyroidism admitted from Shenzhen Second People’s Hospital from January 2015 to June 2016 were hyperthyroidism group and 45 healthy subjects were selected as control group. Electrochemical analysis and enzyme-linked immunosorbent assay (ELISA) were used to detect thyroid hormones in all the subjects and bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Thyroid hormone levels and bone metabolism were compared between the two groups, and the correlation was analyzed by Spearman. Results The levels of T_3, T_4, FT_3, FT_4, TSH, NBAP and CT in hyperthyroidism group were significantly higher than those in control group (P <0.05). The BMD level in observation group was significantly lower than that in control group (P < 0.05). There was a positive correlation between T_3, T_4, FT_3, FT_4, TSH and NBAP, CT in the two groups, and a negative correlation with BMD (P <0.05). Conclusion Hyperthyroidism patients with abnormal thyroid hormone levels can lead to bone resorption and bone metabolism disorders, decreased bone mineral density, early intervention should be to avoid the occurrence of osteoporosis.