本文叙述一例混合性结缔组织病和持续低血清补体:水平,它的肾功能不足及肾病综合征继发于免疫复合物性肾小球肾炎。病人女,37岁,因两年来无畸形的多关节肿痛、胸痛及失去体重55磅,检查见眼周日光性斑疹,指(趾)皮肤硬化,张口困难及手、踝和膝的滑膜中度肿胀增厚而两次住院,其间相隔4个月。第一次住院时尿常规见蛋白(++)伴脓尿和镜下血尿;还发现透明和颗粒管型。补体(C′_3)为67毫克/100毫升(正常145±22毫克/100毫升);补体(C′_4为15毫克/100毫升(正常32±19毫克/100毫升)。可提取 This article describes a case of mixed connective tissue disease and persistent low serum complement: levels, its renal insufficiency and nephrotic syndrome secondary to immune complex glomerulonephritis. A 37-year-old female patient with multiple joint pain, chest pain and loss of body weight of 55 pounds, who had no deformity for two years, was examined for glaucoma on the eyes, skin sclerosis on the toes, difficulty in mouth opening, and slip on the hands, ankles and knees Moderate swelling and thickening of the membrane were hospitalized twice, with an interval of 4 months. Urine routinely seen on the first hospital visit protein (++) with pyuria and microscopic hematuria; also found transparent and granular tube type. Complement (C’_3) is 67 mg / 100 ml (normal 145 ± 22 mg / 100 ml); complement (C’_4 is 15 mg / 100 ml (normal 32 ± 19 mg / 100 ml)