论文部分内容阅读
目的:研究舒风宁痛胶囊对痛风症的药理作用。方法:以足跖注射1%的角叉菜胶造成大鼠足跖肿胀模型,观察舒风宁痛胶囊0.06,0.018,0.006 g.kg-1ig 7,15 d对足跖厚度的影响。饲料中加入5%的氧嗪酸钾和1%的尿酸,15 g/只,限量喂食24 d造成大鼠痛风性肾病模型,观测给药11,24 d血尿酸水平。采用热板法和扭体反应测定给药7,15 d小鼠的痛阈,小鼠剂量均为0.1,0.03,0.01 g.kg-1。用酵母诱导出小鼠高尿酸血症,测定给药15 d血尿酸水平。结果:舒风宁痛胶囊高量0.06,0.018 g.kg-1用药7～15 d后可显著对抗角叉菜胶诱发的大鼠足跖炎性肿胀。0.1,0.03 g.kg-1对小鼠具有显著的镇痛作用。舒风宁痛胶囊0.06,0.018 g.kg-111,24 d可显著对抗氧嗪酸钾诱发的大鼠高尿酸血症的血尿酸的水平,0.1,0.03 g.kg-1用药15 d可显著对抗酵母膏诱发的小鼠高尿酸血症的血尿酸的水平。结论:舒风宁痛胶囊对痛风有良好的治疗作用。
Objective: To study the pharmacological effects of Shufengningtong Capsule on gout. Methods: The rat paw edema model was induced by 1% carrageenin injection, and the effect of Shufeng ningtong capsule 0.06,0.018,0.006 g.kg-1ig 7,15 d on plantar thickness was observed. The feed was supplemented with 5% oteracil potassium and 1% uric acid, 15 g / kg, and the rats were fed with the limited diet for 24 days to induce the gouty nephropathy model. The blood uric acid levels were observed on the 11th and 24th day. The pain threshold of mice administered for 7 and 15 d was determined by hot plate method and writhing reaction. The dose of mice was 0.1, 0.03 and 0.01 g.kg-1 respectively. The mice were induced with hyperuricemia by using yeast, and the serum uric acid level was measured 15 d after administration. Results: Shufeng Ning Tong capsule high doses of 0.06,0.018 g.kg-1 7 to 15 days after treatment can significantly antagonize carrageenan-induced rat paw edema swelling. 0.1,0.03 g.kg-1 had a significant analgesic effect on mice. Shufeng Ning Tong capsule 0.06,0.018 g.kg-111,24 d significantly against potassium oxonic acid potassium-induced hyperuricemia in serum uric acid levels, 0.1,0.03 g.kg-1 drug 15 d significantly against yeast Cream induced hyperuricemia in mice with uric acid levels. Conclusion: Shufengningtong Capsule has a good therapeutic effect on gout.