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In this paper, we introduce a novel method named chemiluminescence mediated sono dynamic diagnosis (SDD), which is designed as follows: sonosensitizer is used to localize the cancer tissue, and is sonosensitized by the ultra- sound field to produce oxygen free radicals. Then, another agent, FCLA (fluoresceinyl cypridina luciferin analog), re-acts with 1O2 to efficiently transform the chemical energy of 1O2 to photons, thus a strong chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of chemiluminescence mediated SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. This method could have potential applica-tions in clinics for early stage tumor diagnosis.
In this paper, we introduce a novel method named chemiluminescence mediated sono dynamic diagnosis (SDD), which is designed to follow: sonosensitizer is used to localize the cancer tissue, and is sonosensitized by the ultra- sound field to produce oxygen free radicals. Then , another agent, FCLA (fluoresceinyl cypridina luciferin analog), re-acts with 1O2 to efficiently transform the chemical energy of 1O2 to photons, thus strong emission of a chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of chemiluminescence mediated SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. This method could have potential applica-tions in clinics for early stage tumor diagnosis.