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CD45是位于白细胞表面的白细胞共同抗原 (leukocytecommonantigen, L CA), 属于单链跨膜大分子糖蛋白家族,高水平地表达在淋巴细胞以及除红细胞和血小板之外的所有造血细胞上。现已证实至少有 9种异构体 (isoform), 由 4 ~6个外显子交替剪接而成。这些异构体的胞外结构各不
CD45 is a leukocytecommonantigen (L CA) on the surface of leukocytes. It belongs to the single-chain transmembrane large glycoprotein family and is highly expressed on lymphocytes and on all hematopoietic cells except erythrocytes and platelets. It has now been confirmed that at least nine isoforms are alternatively spliced from four to six exons. The extracellular structures of these isomers are different