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目的:探讨补充维生素D对慢性阻塞性肺疾病(COPD)患者骨密度及炎症因子的影响。方法:将维生素D缺乏的COPD患者随机分成观察组175例和对照组175例,两组常规治疗相同,观察组加用骨化三醇胶丸(0.25μg·d-1)治疗,比较两组治疗3个月后骨密度、炎症因子及肺功能的差别。结果:1治疗后,观察组血钙、25(OH)D、骨密度和T值均显著高于对照组,血磷、TNF-α和IL-6均显著低于对照组,差异均有统计学意义(P<0.05)。2治疗后,观察组第l秒用力呼气容积(FEV1)、第l秒用力呼气容积/肺功能包括用力肺活量(FEV1/FVC)、单位肺泡一氧化碳弥散量(DLCO/VA)均显著高于对照组,差异均有统计学意义(P<0.05)。结论:补充维生素D可提高COPD患者骨密度,降低炎症因子水平,并改善肺功能。
Objective: To investigate the effect of vitamin D supplementation on bone mineral density (BMD) and inflammatory cytokines in patients with chronic obstructive pulmonary disease (COPD). Methods: COPD patients with vitamin D deficiency were randomly divided into observation group (175 cases) and control group (175 cases). The two groups were treated routinely. The observation group was treated with calcitriol capsule (0.25μg · d-1) 3 months after treatment, bone mineral density, inflammatory factors and lung function differences. Results: After treatment, the levels of serum calcium, 25 (OH) D, BMD and T in the observation group were significantly higher than those in the control group. The levels of serum phosphorus, TNF-α and IL-6 in the observation group were significantly lower than those in the control group Significance (P <0.05). After 2 treatments, FEV1, FEV1, FEV1 / FVC and DLCO / VA in the observation group were significantly higher than those in the FEV1 group Control group, the difference was statistically significant (P <0.05). CONCLUSIONS: Vitamin D supplementation increased bone mineral density (BMD), decreased the level of inflammatory cytokines and improved lung function in COPD patients.