目的研究甘草黄酮脂质体制备的最佳方法。方法用4种不同的方法制备脂质体,采用UV法测定包封率,检测波长286nm,根据包封率筛选制备甘草黄酮脂质体的最佳方法。结果薄膜法制备的甘草黄酮脂质体包封率达80.8%。结论薄膜法制备工艺简单、易掌握,可用于制备甘草黄酮的脂质体。 Objective To study the best method of preparation of licorice flavonoids liposomes. Methods Four different methods were used to prepare liposomes. The entrapment efficiency was determined by UV method. The optimal wavelength was 286 nm. The best method for preparing liposomes from licorice flavonoids was screened by entrapment efficiency. Results The encapsulation efficiency of glycyrrhiza flavonoids liposomes was 80.8%. Conclusion Thin film preparation process is simple, easy to grasp, can be used to prepare licorice flavonoids liposomes.