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应用纯化提取的3种细菌染色体DNA进行体内抗肿瘤免疫实验。结果表明,大肠埃希菌、铜绿假单胞菌和长双歧杆菌 DNA由于含有大量的非甲基化的CpG二核苷酸为核心的序列(称为 CpG motif),均能够诱导NK细胞和单核细胞的激活,从而起到抗肿瘤免疫的作用。为微生物DNA制剂作为生物反应修饰剂(BRM)应用于抗肿瘤免疫提供了科学依据。
Purified and extracted three kinds of bacterial chromosomal DNA were used for in vivo anti-tumor immunity experiments. The results showed that the sequences of E. coli, Pseudomonas aeruginosa, and B. longum that contained a large number of unmethylated CpG dinucleotides as cores (called CpG motifs) were able to induce NK cells and The activation of monocytes thus plays a role in anti-tumor immunity. It provides a scientific basis for the application of microbial DNA preparations as biological response modifiers (BRM) for anti-tumor immunity.