应用谷氨酰胺对２０例活动期小肠Ｃｒｏｈｎ病患者进行临床对照治疗，通过病人口服乳果糖及甘露醇后利用高效液相色谱法测定尿中两者的比值，分别观察服用谷氨酰胺７天及１５天后对照组和病例组肠粘膜通透性的变化。实验表明，谷氨酰胺具有稳定肠粘膜结构的屏障功能，有助于肠粘膜损害的修复及疾病的缓解。谷氨酰胺用于Ｃｒｏｈｎ病治疗，初步显示了较好的疗效，有望成为一种较好的治疗手段。 Application of glutamine in 20 cases of active Crohn disease in patients with controlled clinical treatment of patients by oral administration of lactulose and mannitol by high performance liquid chromatography determination of urinary ratio of the two were observed after taking glutamine 7 days and Changes of intestinal mucosal permeability in control group and case group after 15 days. Experiments show that glutamine has a stable barrier function of intestinal mucosa structure, contribute to the repair of intestinal mucosal damage and disease remission. Glutamine for the treatment of Crohn disease, initially showed a good effect, is expected to become a better treatment.