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目的:比较甲氨蝶呤(MTX)穿刺介入与腹腔镜手术治疗异位妊娠的疗效。方法:80例异位妊娠患者根据意愿选择手术方式,MTX组采用超声引导下MTX穿刺介入治疗,腹腔镜组采用腹腔镜保守手术治疗,比较两组疗效及对生育功能的影响。结果:MTX组患者治愈率及血3-HCG降至正常时间与腹腔镜组相近(P>0.05),但手术时间、术中出血量均少于腹腔镜组(P<0.05或0.01);两组患者术后输卵管通畅情况及术后2年再次异位妊娠率相近(P>0.05),MTX组术后2年宫内妊娠生育率高于腹腔镜组(P<0.05)。结论:超声引导下MTX穿刺介入治疗异位妊娠能取得与腹腔镜保守手术治疗相近的疗效。
Objective: To compare the efficacy of methotrexate (MTX) intervention and laparoscopic surgery for ectopic pregnancy. Methods: Eighty patients with ectopic pregnancy were selected according to their wishes. MTX group was treated with MTX guided by ultrasound. Laparoscopic operation was performed by laparoscopy. The curative effect and reproductive function were compared between the two groups. Results: The cure rate and blood 3-HCG decreased to normal in MTX group compared with laparoscopic group (P> 0.05), but the operation time and intraoperative blood loss were less than those in laparoscopic group (P <0.05 or 0.01) The tubal patency and the rate of ectopic pregnancy again after 2 years were similar in the two groups (P> 0.05). The intrauterine pregnancy rate in MTX group was significantly higher than that in laparoscopic group at 2 years after operation (P <0.05). Conclusion: Ultrasound-guided MTX puncture interventional treatment of ectopic pregnancy and Laparoscopic surgery can achieve similar results.