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近年来,氨苯砜已广泛使用在各种皮肤病的治疗上,由砜类药引起的严重副作用有溶血、正铁血红蛋白血症、中性白细胞减少和粒细胞缺乏症,此外尚有厌食、黄疸、皮疹、精神病和头痛。曾报道10例长期使用氨苯砜后引起多发性神经病变,主要是运动症状,特别是手内在肌的软弱与萎缩,也发现有感觉症状。肌电图检查发现手部肌肉有去神经的症状,而末稍感觉传递正常。本文报道1例患有持久性隆起性红斑的27岁女性患者,在连续氨苯砜治疗5年之后(近18个月
In recent years, dapsone has been widely used in the treatment of various skin diseases, the serious side effects caused by sulfone drugs are hemolysis, methemoglobinemia, neutropenia and agranulocytosis, in addition there are anorexia, Jaundice, rash, mental illness and headache. It has been reported in 10 cases of long-term use of dapsone caused by multiple neuropathy, mainly motor symptoms, especially hand weakness and atrophy of the intrinsic muscle, but also found to have sensory symptoms. Electromyography found hand muscle denervation symptoms, and the final sensory transmission is normal. This article reports a 27-year-old female patient with persistent elevated erythema who, after 5 years of continuous dapsone treatment (nearly 18 months