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目的观察国产冻干人用狂犬病疫苗(人二倍体细胞)在不同年龄人群中的不良反应率,为儿童及老人安全有效地使用狂犬病疫苗提供参考。方法选择乌鲁木齐市疾病预防控制中心犬伤门诊接种狂犬病疫苗者作为研究对象,按年龄分为儿童组、普通组、老人组。观察记录研究对象每一剂次接种30 min后的即时反应及72 h内的局部及全身免疫反应,统计分析各组不良反应发生率的差异。结果所有研究对象接种疫苗后反应轻微,未发生III级及以上的不良反应。所有不良反应均在72 h内自行恢复。其中儿童组局部不良反应发生率为7.46%,全身不良反应发生率为2.98%;普通组局部不良反应发生率为7.14%,全身不良反应发生率为3.76%;老年组局部不良反应发生率为7.69%,全身不良反应发生率为2.56%。各组间局部不良反应发生率差异无统计学意义(χ2=0.204,P>0.05);各组间全身不良反应发生率差异无统计学意义(χ2=3.529,P>0.05)。结论国产冻干人用狂犬病疫苗接种后,儿童和老人发生不良反应的情况和普通人群相当,总不良反应发生率较低,可放心应用于儿童和老人。
Objective To observe the rate of adverse reactions of domestic lyophilized human rabies vaccine (human diploid cells) in different age groups and to provide a reference for the safe use of rabies vaccine in children and the elderly. Methods Inoculation of rabies vaccine in dogs in outpatient department of Urumqi Center for Disease Control and Prevention was selected as research object and divided into children group, common group and old group according to age. Observe and record the immediate response of each dose of vaccination 30 min after each dose and the local and systemic immune response within 72 h, and statistically analyze the difference of adverse reactions in each group. Results All subjects responded mildly after vaccination, with no grade III or higher adverse reactions. All adverse reactions recovered within 72 h. Among them, the incidence of local adverse reactions in children was 7.46%, the incidence of systemic adverse reactions was 2.98%; the incidence of local adverse reactions in general group was 7.14%, the incidence of systemic adverse reactions was 3.76%; the incidence of local adverse reactions in elderly group was 7.69 %, The incidence of systemic adverse reactions was 2.56%. There was no significant difference in the incidence of local adverse reactions between the two groups (χ2 = 0.204, P> 0.05). There was no significant difference in the incidence of systemic adverse reactions between the two groups (χ2 = 3.529, P> 0.05). Conclusion Domestic rabies vaccine with rabies vaccination, the incidence of adverse reactions in children and the elderly and the general population, the lower the incidence of adverse reactions can be safely applied to children and the elderly.