日本微生物化学研究所最近利用新的筛选方法获得一些新的抗肿瘤抗生素。其中由假单孢菌产生的抗生素bactobolin(图1)的结构,类似于由链霉菌产生的actinobolin。它能够抑制L1210白血病,抑制B淋巴细胞的能力比抑制T细胞强。在对羊红细胞免疫时腹腔内注射该抗生素,对小鼠脾脏的抗体形成细胞数目或迟发型高敏感性没有影响;但在免疫1、2或3天后注射,则显著减少抗体形成细胞数,但不影响超 Japan Institute of Microbiology recently using new screening methods to obtain some new antitumor antibiotics. The structure of the antibiotic bactobolin (FIG. 1) produced by Pseudomonas is similar to actinobolin produced by Streptomyces. It inhibits L1210 leukemia and suppresses B lymphocytes more strongly than T cells. Intraperitoneal injection of this antibiotic on herniocytes did not affect the number of antibody-forming cells or delayed hypersensitivity in spleen of mice; however, injection at 1, 2 or 3 days after immunization significantly reduced the number of antibody-forming cells, Does not affect the super