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自Hippocrates时期开始即认为发热对身体有利,自19世纪Bernard证实动物体温超过正常5～6℃可以死亡以后,即认为发热对机体有害。因此,至今仍把退热疗法尤其是在儿童中作为常规应用。虽然许多医生及父母强调退热疗法可改善发热儿童的舒适度及行为,但亦无令人信服的证据表明发热的自然病程对机体有害。相反,有的研究表明发热有助于实验感染动物的存活,而退热疗法可增加死亡率,并有相当多的实验证据表明,当发热时人类免疫防御功能的变化比体温正常时更好。本文报道扑热息痛对发热儿童利弊的随机、双盲、安慰剂对照研究结果。对象及方法对象为发热至少38℃、病程≤4天、年龄6个月～6岁,患儿无细菌感染灶证据。诊断后发现有细菌感染证据以及有发热病史及热性惊厥史及体温≥41℃者不列入研究对象。治疗组发热时给
Fever is considered beneficial to the body since the beginning of the Hippocrates period and has been considered to be harmful to the body since the 19th century Bernard confirmed that animals can die when their body temperature exceeds normal 5-6 ° C. As a result, antipyretics are still routinely used, especially in children. Although many doctors and parents emphasize that antipyretic therapy can improve the comfort and behavior of children with fever, there is no convincing evidence that the natural course of fever is harmful to the body. In contrast, some studies have shown that fever helps to test the survival of infected animals, and that antipyretics increase mortality and there is considerable empirical evidence that human immune defenses function better than normal when fever occurs. This article reports the results of a randomized, double-blind, placebo-controlled study of the pros and cons of acetaminophen in children with fever. Subjects and methods The object is fever at least 38 ℃, duration ≤ 4 days, age 6 months to 6 years old, no evidence of bacterial infection in children. After diagnosis, there was evidence of bacterial infection as well as a history of fever and a history of febrile seizures and body temperature ≥41 ℃ were not included in the study. Treatment group fever to