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目的:探讨三种抗缺氧药物对筑路工人急进高海拔地区不同时间血红蛋白的影响。方法:受试者随机分为服药组A组(复方1号)、B组(复方2号)、C组(复方3号)和对照组(D组),每组(23~24)人。启程时开始服药,每天早、中、晚各服药一次,连续服药3周。到达海拔4600m施工现场第1天、3天、7天、15天进行血红蛋白测定,与服药前血红蛋白比较。结果:进驻后第一天各组血红蛋白与服药前组内比较,差别有非常显著性(P<0.01);第15天复方2号组、安慰剂组与服药前组内比较,差别有显著性(P<0.05)。第1天与第3天、第15天各组组内比较,差别有显著性(P<0.05);第一天与第7天比较,除复方2号组外其余各组组内比较,均差别有非常显著性(P<0.01);第3天与第15天复方1号组、复方3号组组内比较,差别有显著性(P<0.05)。结论:三种抗缺氧药物均不同程度改善红细胞携氧功能,以复方1号、复方3号效果较好。
Objective: To investigate the effect of three anti-hypoxia drugs on hemoglobin of road construction workers in different areas at different altitudes. Methods: The subjects were randomly divided into treatment group A (compound 1), group B (compound 2), group C (compound 3) and control group (group D), each group (23-24). Start taking medication, daily morning, middle and late medication, medication for 3 weeks. Arrival at 4600m at the construction site on the first day, three days, seven days, 15 days hemoglobin determination, compared with medication hemoglobin. Results: There was a significant difference between hemoglobin in each group on the first day and the pre-administration group (P <0.01). On the 15th day, there was significant difference between the compound 2 group and the placebo group (P <0.05). The difference between the first day and the third day and the fifteenth day in each group was significant (P <0.05). On the first day and the seventh day, The difference was significant (P <0.01). On the 3rd and 15th days, there was a significant difference between compound 1 and compound 3 (P <0.05). Conclusion: The three kinds of anti-hypoxia drugs can improve the oxygen-carrying capacity of erythrocytes to different extent, and the effects of Fufang 1 and Fufang 3 are better.