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本文报道复方有机锗(简称CoGe-132)、有机锗(简称Ge-132)和环磷酰胺(简称CY)对小鼠移植性肝癌实体瘤的抗癌作用及其对小鼠肝脏微粒体的细胞色素P-450含量和乳酸脱氢酶(简称LDH)活性的影响。给荷瘤小鼠连续灌胃CoGe-132 125mg/kg,10天,停药继续观察10天时,抑制率为79.4％,p<0.01。用同法,Ge-132灌胃100mg/kg时,其抑制率为45％,p<0.05。CY灌胃25mg/kg时,抑制率为51.1％,p<0.025。肝癌实体瘤小鼠经CoGe-132治疗,肿块明显缩小,肝微粒体细胞色素p-450含量比肝癌实体瘤对照组显著下降,而LDH活性也降低,接近于正常小鼠对照组水平。在Ge-132组,细胞色素P-450含量和LDH活性都恢复到接近于正常小鼠对照组水平。CY组与CoGe-132组较相近。
This article reports the anti-cancer effect of compound organic germanium (CoGe-132), organic germanium (Ge-132) and cyclophosphamide (CY) on transplanted liver cancer solid tumors and their effects on mouse liver microsomal cells. The effect of pigment P-450 content and lactate dehydrogenase (LDH) activity. The tumor-bearing mice were given orally with CoGe-132 at a dose of 125 mg/kg for 10 days. The discontinuation rate was 79.4%, p<0.01, when the discontinuation was continued for 10 days. Using the same method, when Ge-132 was intragastrically administered at 100 mg/kg, the inhibition rate was 45%, p<0.05. When CY was intragastrically administered 25 mg/kg, the inhibition rate was 51.1%, p<0.025. Tumors treated with CoGe-132 in solid tumors of hepatocarcinoma were significantly reduced in size, and the content of cytochrome p-450 in hepatic microsomes was significantly lower than that in the control group of solid tumors of hepatocellular carcinoma, and LDH activity was also decreased, which was close to that of normal mice. In the Ge-132 group, the cytochrome P-450 content and LDH activity both returned to levels close to those of the normal mouse control group. The CY group was similar to the CoGe-132 group.