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目的:窦卵是女性宫腔内的泡状细胞,与女性卵巢的发育及功能密切相关。本研究针对体外受精(IVF)周期中基础窦卵泡数(antral follicle count,AFC)的变化情况,探讨AFC对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012年1月至2012年12月在我院生殖医学中心接受体外受精-胚胎移植的157例患者的临床资料,根据基础窦卵泡数将所选病例分为A组(bAFC≥10)和B组(bAFC<10)。对比并分析两组研究对象的促性腺激素(Gn)的用量及使用时间、获卵数、人绒毛膜促性腺激素(HCG)注射日的血清中雌激素(E2)水平、受精率、临床妊娠率等。结果:A组患者的Gn用量、HCG日E2值、获卵数及临床妊娠率均显著高于B组,差异具有统计学意义(P<0.05);两组患者的年龄和基础卵泡刺激素水平差异显著且具有统计学意义(P<0.05);两组患者的不孕原因、不孕年限及助孕方式无明显差异(P>0.05)。结论:基础窦卵泡对体外受精女性促排卵周期的卵巢反应及助孕结局具有一定的预测价值,其数量的多少可作为促排卵过程中评价卵巢反应性的参考指标,应在临床进一步推广。
Objective: Sinus ovary is a female intrauterine vesicular cells, which is closely related to the development and function of female ovary. In this study, the changes of antral follicle count (AFC) in vitro fertilization (IVF) cycle and the prognostic value of AFC in ovarian response were analyzed to provide a theoretical basis for clinical research. Methods: The clinical data of 157 patients undergoing in vitro fertilization and embryo transfer from January 2012 to December 2012 in our hospital were retrospectively analyzed. The selected cases were divided into group A (bAFC≥ 10) and Group B (bAFC <10). The amount and time of gonadotropin (Gn), the number of oocytes retrieved, serum estrogen (E2) level on the day of injection of human chorionic gonadotropin (HCG), fertilization rate, clinical pregnancy were compared and analyzed. Rate and so on. Results: The amount of Gn, E2 value on day of HCG, number of oocytes retrieved and clinical pregnancy rate in group A were significantly higher than those in group B (P <0.05). The age and the level of basal follicle stimulating hormone (P <0.05). The cause of infertility, duration of infertility and methods of pregnancy-assisted pregnancy in both groups had no significant difference (P> 0.05). CONCLUSION: The basal antral follicles have some predictive value on the ovarian response and pregnancy-promoting outcome of IVF women. The number of them can be used as a reference index to evaluate ovarian response during ovulation induction and should be further popularized in clinic.