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对我院1989年以来住院的急性早幼粒细胞白血病(M_3,APL)患者29例,应用全反式维甲酸(ATRA)加化疗的方法治疗,并跟踪随访3年,取得较满意的疗效,报道如下。 1 资料与方法 1.1 病例选择 1989年以来住院患者29例,男17例,女12例,年龄13～53岁,中位年龄34岁。经血象、骨髓象及细胞化学检查符合FAB分类中M_3型的诊断标准。 1.2 治疗方法 1.2.1 诱导治疗:确诊后即口服ATRA 40～120mg/d,其中2例在诱导期间死亡。余27例均在服用ATRA后达到完全
29 cases of acute promyelocytic leukemia (M_3, APL) hospitalized in our hospital since 1989 were treated with all-trans retinoic acid (ATRA) plus chemotherapy, followed up for 3 years and achieved satisfactory results. Reported as follows. 1 Materials and Methods 1.1 Case Selection Since 1989, 29 cases of hospitalized patients, 17 males and 12 females, aged 13 to 53 years, with a median age of 34 years. The menstrual blood, bone marrow and cytochemical examination in line with FAB classification M_3-based diagnostic criteria. 1.2 treatment 1.2.1 induction therapy: diagnosis of oral ATRA 40 ~ 120mg / d, of which 2 died during induction. The remaining 27 patients achieved complete after taking ATRA