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目的:探讨甲状腺球蛋白检测对甲状腺良恶性结节的鉴别诊断价值。方法:选择甲状腺结节76例,术前常规测定甲状腺球蛋白(TG)、促甲状腺素(TSH)及甲状腺球蛋白抗体(TGAb)水平,并根据术后病理结果分为甲状腺乳头状癌组(观察组)29例和甲状腺腺瘤组(对照组)47例,分析术前TG等检测对甲状腺结节良恶性鉴别诊断价值。结果:(1)观察组TG水平为(24.73±23.02)ng/ml,TSH为(2.13±1.63)μU/ml,TGAb为(23.15±15.17)U/ml;对照组TG水平为(42.72±31.25)ng/ml,TSH为(3.28±5.83)μU/ml,TGAb为(18.16±8.65)U/ml。观察组TG水平显著低于对照组(P<0.05),两组TSH及TGAb水平差异不显著(P>0.05)。(2)血清TG的ROC曲线下面积(AUC)仅为0.306,提示其作为鉴别甲状腺结节良恶性质的准确度较差。结论:TG检测对甲状腺结节的良恶性鉴别仅有一定参考价值,还须结合超声及穿刺等检查结果综合判定。
Objective: To investigate the differential diagnosis of thyroid globulin in benign and malignant thyroid nodules. Methods: 76 cases of thyroid nodules were selected. Thyroglobulin, thyroid-stimulating hormone (TSH) and thyroglobulin antibody (TGAb) levels were routinely measured preoperatively and were divided into thyroid papillary carcinoma group (N = 29) and thyroid adenoma (n = 47). The value of preoperative TG and other tests in differential diagnosis of benign and malignant thyroid nodules was analyzed. Results: (1) TG level in observation group was (24.73 ± 23.02) ng / ml, TSH was (2.13 ± 1.63) μU / ml and TGAb was (23.15 ± 15.17) U / ) ng / ml, TSH was (3.28 ± 5.83) μU / ml and TGAb was (18.16 ± 8.65) U / ml. The level of TG in observation group was significantly lower than that in control group (P <0.05). There was no significant difference in TSH and TGAb between the two groups (P> 0.05). (2) The area under the ROC curve (AUC) of serum TG was only 0.306, suggesting that its accuracy of differentiating benign from malignant thyroid nodules was poor. Conclusion: TG detection of thyroid nodules benign and malignant differentiated only have some reference value, but also combined with ultrasound and puncture and other test results comprehensive judgment.