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白血病耐药性是自血病治疗中的难点,也是目前白血病治疗研究领域的热点之一。本研究项目以人白血病多药耐药细胞K562/ADM细胞为模型,通过系列系统研究工作,提出和建立了白血病细胞获得性耐药的逆转、分化诱导、促凋亡和预防的综合干预策略,取得了如下主要成果。 1.白血病细胞耐药的诱导分化策略白血病细胞发生耐药后其生物学特性发生了许多变化,本研究对耐药白血病细胞尝试性进行了分化诱导研究,证
Leukemia drug resistance is the difficulty in the treatment of leukemia and is also one of the hot spots in the field of leukemia treatment. In this study, human leukemia multi-drug resistant cell K562 / ADM cells as a model, through a series of systematic research, proposed and established leukemia cell acquired resistance reversal, differentiation induction, apoptosis and prevention of comprehensive intervention strategy, Achieved the following main results. 1. Leukemia cell differentiation induced by drug resistance Leukemia cells after the emergence of a number of biological changes in the biological characteristics of this study of drug-resistant leukemia cells were induced differentiation studies