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目的:研究紫外线照射充氧血液输注(UBIO)在急性白血病化疗中的作用。方法:38例急性白血病患者随机分为两组,在化疗后分别输紫外线照射的充氧血液和非照射的血液。结果:UBIO 组患者白细胞和血小板在化疗后第二周较对照组有明显升高(P<0.01),化疗后的不良反应症状明显改善,出血感染发生率减少,30天化疗间歇期的输血量由非照射时的2.8次×400ml 降为2.1次×400ml(P<0.05)。治疗后1个月 UBIO 组 CD_4、CD_8、CD_4/CD_8升高,分别为38.2%,23.6%和1.62,对照组分别为26.1%,19.7%和1.32;IgM、IgG 前者较后者也有明显升高,IgA 和 C_3无变化,同时观察到 UBIO 组可明显降低骨髓中的原始细胞及早幼粒细胞比率(P<0.01),患者的完全缓解和部分缓解比例增加。结论:UBIO 具有促进化疗后骨髓造血恢复,降低出血、感染发生,改善症状,并具有促进细胞免疫和体液免疫功能恢复的效应,其作用机制有待进一步研究。
Objective: To study the role of ultraviolet irradiation and oxygenated blood transfusion (UBIO) in the chemotherapy of acute leukemia. METHODS: Thirty-eight patients with acute leukemia were randomly divided into two groups. After chemotherapy, the blood was irradiated with ultraviolet blood and non-irradiated blood. RESULTS: In the UBIO group, leukocytes and platelets were significantly higher in the second week after chemotherapy than in the control group (P<0.01). The adverse reaction symptoms after chemotherapy were significantly improved, the incidence of bleeding infection was reduced, and the number of blood transfusions during the 30-day chemotherapy interval was significantly increased. From the non-irradiation 2.8 times × 400ml to 2.1 × 400ml (P <0.05). At 1 month after treatment, CD4, CD8, and CD4/CD8 increased in UBIO group, which were 38.2%, 23.6%, and 1.62, respectively, in the control group, 26.1%, 19.7%, and 1.32; IgM and IgG were significantly higher than the latter. There was no change in IgA and C_3, and it was observed that the UBIO group significantly reduced the ratio of promyelocytic and promyelocytic cells in the bone marrow (P<0.01), and the patient’s complete remission and partial remission rates increased. Conclusion: UBIO has the effect of promoting bone marrow hematopoietic recovery after chemotherapy, reducing bleeding, infection, improving symptoms, and has the effect of promoting cellular and humoral immune function recovery, and its mechanism of action needs further study.