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目的探讨经尿道前列腺切除术(TURP)联合抗雄激素在晚期前列腺癌治疗中的效果。方法对2008-2010年诊断为晚期前列腺癌合并LUTS的36例患者进行总结,分析TURP术前及术后3、6月患者的IPSS评分、最大尿流率、残余尿及QOL(quality of life)评分,放射免疫法检测治疗前后血清PSA的水平。结果术后3月及6月IPSS评分、最大尿流率、残余尿及QOL评分与术前相比差异有统计学意义(P<0.05)。术后PSA水平呈下降趋势,术后3月及12月PSA水平较治疗前明显下降(P<0.05)。手术后未见电切综合征的出现,无围手术期患者死亡。结论 TURP联合抗雄激素治疗晚期前列腺癌合并LUTS的患者,在短期内可以解决患者下尿路梗阻症状,改善生活质量,获得了较为满意的临床效果。
Objective To investigate the effect of transurethral resection of the prostate (TURP) combined with anti-androgen in the treatment of advanced prostate cancer. Methods Thirty-six patients diagnosed as advanced prostate cancer with LUTS from 2008 to 2010 were analyzed. IPSS score, maximal uroflow rate, residual urine and QOL (quality of life) were analyzed before and after TURP. Score, radioimmunoassay before and after treatment to detect serum PSA levels. Results The IPSS score, maximal uroflow rate, residual urine and QOL score at 3 months and 6 months postoperatively were significantly different from those before operation (P <0.05). The level of PSA decreased after operation, and the levels of PSA decreased significantly at March and December after operation (P <0.05). No surgical resection syndrome appeared after surgery, no perioperative deaths. Conclusion TURP combined with anti-androgen therapy in patients with advanced prostate cancer and LUTS can solve the symptoms of lower urinary tract obstruction and improve the quality of life in short term, and obtain satisfactory clinical results.