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目的观察胃液pH值变化对幽门螺杆菌阳性十二指肠球溃疡治疗效果的影响。方法幽门螺杆菌阳性十二指肠球溃疡患者120例,随机分成3组,每组40例,治疗疗程均为4周。A组给予根除幽门螺杆菌治疗1周后继续服用奥美拉唑肠溶胶囊3周完成治疗。B组首先给予口服奥美拉唑肠溶胶囊20mg,2次/d,1周,再给予根除幽门螺杆菌治疗1周后继续服用奥美拉唑肠溶胶囊2周完成治疗。C组给予口服奥美拉唑肠溶胶囊20mg,2次/d,2周,再给予根除幽门螺杆菌治疗1周后继续服用奥美拉唑肠溶胶囊1周完成治疗。结果 A组幽门螺杆菌的根除率为64.9%,B组及C组幽门螺杆菌的根除率分别为95.0%、92.5%,B组、C组幽门螺杆菌的根除率显著高于A组(P<0.05);A组溃疡愈合率70.3%,B、C组溃疡愈合率均为95.0%,B组、C组溃疡愈合率显著也高于A组(P<0.05)。结论改变胃液pH值,增强根除幽门螺杆菌药物疗效,可显著提高幽门螺杆菌的根除率及溃疡愈合率。
Objective To observe the effect of pH value of gastric juice on the therapeutic effect of Helicobacter pylori-positive duodenal ulcer. Methods 120 cases of Helicobacter pylori-positive duodenal ulcer patients were randomly divided into 3 groups, 40 cases in each group, the treatment course was 4 weeks. Group A was given treatment of eradication of Helicobacter pylori 1 week after taking omeprazole enteric-coated capsules for 3 weeks to complete the treatment. Group B was first given oral omeprazole enteric-coated capsules 20mg, 2 times / d, 1 week, and then given to eradicate Helicobacter pylori treatment for 1 week and then continue taking omeprazole enteric-coated capsules for 2 weeks to complete the treatment. Group C was orally given omeprazole enteric-coated capsules 20mg, 2 times / d, 2 weeks, and then give eradication of Helicobacter pylori treatment for 1 week and then continue taking omeprazole enteric-coated capsules for 1 week to complete the treatment. Results The eradication rate of Helicobacter pylori in group A was 64.9%, and the eradication rates of Helicobacter pylori in groups B and C were 95.0% and 92.5% respectively. The eradication rates of Helicobacter pylori in group B and C were significantly higher than those in group A (P <0.05). The healing rate of ulcer in group A was 70.3%, and the healing rate in group B and C was 95.0%. The healing rate of ulcer in group B and group C was significantly higher than that of group A (P <0.05). Conclusions Changing the gastric juice pH value and enhancing the eradication effect of H. pylori can significantly improve the eradication rate and ulcer healing rate of Helicobacter pylori.