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目的探讨HBV-DNA、HBs Ag及凝血功能检测在老年慢性乙型肝炎中的应用及临床意义。方法选取2013年1月~2016年1月期间的我院收治的老年慢性乙肝患者110例(年龄均>60岁),分为老年慢性重型乙肝组(A组)为46例,老年慢性乙肝组(B组)64例,作为观察组;同时随机抽选老年组人群110例作为对照组,并称之为老年健康组(C组,年龄均>60岁)。分析不同年龄阶层老年慢性乙肝患者的HBs Ag定量,探讨老年慢性乙肝患者的HBV-DNA与HBs Ag的相关性,同时分析在老年慢性乙肝患者不同HBV-DNA定量分组中凝血功能的特点。结果在老年慢性乙肝患者中,其HBs Ag和患病时间长度呈现负相关的关系。HBV-DNA数值越高,其HBs Ag的水平也越高。HBV-DNA含量越高,PT、APTT、TT的数值也越高,相反,FIB的数值却越低。结论 HBV-DNA与HBs Ag、凝血功能等多方面检测是能够比较客观和科学地反映老年慢性乙型肝炎患者的病情,在老年慢性乙型肝炎患者的诊治和疗效评估中具有积极的临床意义。
Objective To investigate the clinical significance and application of HBV-DNA, HBsAg and coagulation tests in elderly patients with chronic hepatitis B. Methods A total of 110 aged patients with chronic hepatitis B (aged> 60 years) admitted to our hospital from January 2013 to January 2016 were divided into three groups: aged chronic severe hepatitis B (group A), 46 cases, elderly chronic hepatitis B (Group B) as observation group. At the same time, 110 elderly patients were randomly selected as the control group and referred to as elderly healthy group (C group, mean age> 60 years). To analyze the relationship between HBV-DNA and HBs Ag in elderly patients with chronic hepatitis B, and to analyze the characteristics of coagulation in different HBV-DNA quantitative chronic hepatitis B patients. Results In elderly patients with chronic hepatitis B, the HBsAg and the duration of illness showed a negative correlation. The higher the HBV-DNA value, the higher the level of HBs Ag. The higher the HBV-DNA content, the higher the values of PT, APTT and TT, but the lower the value of FIB. Conclusion The detection of HBV-DNA, HBs-Ag, coagulation function and other aspects can reflect objectively and scientifically the condition of elderly patients with chronic hepatitis B, and has positive clinical significance in diagnosis and treatment of senile chronic hepatitis B patients.