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目的 探讨测定β-内啡肽和B型利钠肽在新生儿呼吸困难病因早期诊断中的意义.方法 采用放射免疫法测定36例新生儿呼吸困难患儿(心源性组11例,肺源性组13例,中枢神经组12例)β-内啡肽和B型利钠肽含量.并与15例健康对照组进行比较.结果 心源性组B型利钠肽含量为(512.36±189.45)pg/ml,显著高于肺源性组的(78.62±26.41)pg/ml、中枢神经组的(65.57±22.87)pg/ml及对照组的(66.41±19.01)pg/ml(P<0.01).中枢神经组β_内啡肽含量为(187.34±21.31)pg/ml,显著高于心源性组的(72.48±14.36)pg/ml、肺源性组的(63.23±12.87)pg/ml及对照组的(70.52±13.96)pg/ml(P0.05).结论 β-内啡肽联合B型利钠肽的测定有助于早期鉴别新生儿呼吸困难病因.“,”Objective To study the significance of monitoring beta-endorphin and B-type natriuretic peptide in etiological diagnosis of neonatal dyspnea. Methods The levels of beta-endorphin and B-type natriuretic peptide were measured with radioimmunoassay (RIA) in 34 neonates with dyspnea, of whom dyspnea was cardiogenic in 11 cases(group A), repiratory in 13 cases(group B) and central nervous in 12 cases(group C). The results were compared with those in 15 healthy neonates as the controls(group D). Results The level of B-type natriuretic peptide was (512. 36±189. 45) pg/ml in group A, which was significantly higher than (78. 62±26. 41) pg/ml in group B, (65. 57±22. 87) pg/ml in group C and (66. 41±19. 01) pg/ml in group D (P<0. 01). The level of beta-endorphin was (187. 34±21. 31) pg/ml in group C, which was significantly higher than (72. 48±14. 36) pg/ml in group A, (63. 23±12. 87) pg/ml in group B. and (70. 52±13. 96) pg/ml in group D (F<0. 01). The level of beta-endorphin or B-type natriuretic peptide in group B was similar to that in group D. Conclusion Detection of beta-endorphin and B-type natriuretic peptide is helpful in etiological diagnosis of neonatal dyspnea.