晚发性维生素K缺乏是引起新生儿及婴幼儿颅内出血最常见的病因之一，发病急，病情重，进展快，致残率及病死率高。特别是出血量大者，可迅速引起颅内高压、脑疝而死亡。单纯的保守治疗已日见缺点，即使成功救治，大多也留下脑瘫、脑积水、癫痫等终生后遗症。我科自1997年至今共 Late onset vitamin K deficiency is one of the most common causes of intracranial hemorrhage in newborns and infants. The incidence of acute, severe illness, rapid progression, morbidity and mortality is high. Especially the large amount of bleeding, can quickly lead to intracranial hypertension, hernia and death. Simple conservative treatment has seen shortcomings, even successful treatment, most also leave cerebral paralysis, hydrocephalus, epilepsy and other life-long sequelae. Our department since 1997 a total of