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目的观察米索前列醇联合缩宫素预防剖宫产术中及术后出血的临床效果。方法选择580例产妇,随机分为对照组290与观察组290例。对照组(缩宫素组):于胎儿娩出后缩宫素20u宫体肌内注射,20u加液体中滴入。观察组(米索前列醇+缩宫素组):除同法用缩宫素外,于胎儿娩出后米索前列醇200ug舌下含服,1h后再次舌下含服200ug。观察两组术中及术后24h出血量及不良反应。结果观察组(米索前列醇+缩宫素组)术中及术后24h出血量比对照组(缩宫素组)明显减少,两组间相比差异有统计学意义(P<0.05)。观察组3例出现恶心、无呕吐、腹泻发生,2例寒颤、发热,对照组未出现上述不良反应。结论米索前列醇联合缩宫素预防剖宫产术中及术后出血,效果明显,安全、不良反应小,值得推广使用。
Objective To observe the clinical effect of misoprostol combined with oxytocin in preventing cesarean section and postoperative bleeding. Methods 580 pregnant women were randomly divided into control group 290 and observation group 290 cases. The control group (oxytocin group): intrauterine injection of oxytocin 20u Palace after intrauterine injection, 20u plus liquid instillation. Observation group (misoprostol + oxytocin group): In addition to the same law with oxytocin, the fetus after delivery of misoprostol 200ug sublingual sublingual, 1h sublingual sublingual 200ug. The intraoperative and postoperative 24h blood loss and adverse reactions were observed. Results In the observation group (misoprostol + oxytocin group), the amount of bleeding during and after operation was significantly lower than that of the control group (oxytocin group). There was significant difference between the two groups (P <0.05). In the observation group, nausea, vomiting, diarrhea occurred in 3 cases, chills and fever in 2 cases, and no adverse reactions occurred in the control group. Conclusion Misoprostol combined with oxytocin in preventing cesarean section and postoperative bleeding, the effect is obvious, safe, small adverse reactions, it is worth promoting the use of.