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目的:分析血管形成素(ANG)在鼻咽癌(NPC)患者血循环中的含量及其临床意义。方法:采用酶联免疫吸附试验(ELISA)测定42例NPC患者(NPC组)和30例健康者(对照组)血清ANG水平。结果:NPC组治疗前血清ANG水平为(371.4±123.5)μg/L,显著高于对照组的(292.5±74.2)μg/L(P<0.01),且血清ANG水平随着NPC临床分期的增加而升高(P<0.05);治疗后血清ANG水平为(340.6±112.4)μg/L,比治疗前明显降低(P<0.05),但仍高于对照组(P<0.05)。结论:NPC患者血清ANG水平升高,且其升高的程度与肿瘤的进展有关。
Objective: To analyze the content of angiogenin (ANG) in the blood circulation of patients with nasopharyngeal carcinoma (NPC) and its clinical significance. Methods: The serum levels of ANG in 42 NPC patients (NPC group) and 30 healthy controls (control group) were determined by enzyme-linked immunosorbent assay (ELISA). Results: The levels of ANG in NPC before treatment (371.4 ± 123.5) μg / L were significantly higher than those in control group (292.5 ± 74.2) μg / L (P <0.01), and the levels of serum ANG were increased with the clinical stage of NPC (P <0.05). The level of serum ANG was (340.6 ± 112.4) μg / L after treatment, which was significantly lower than that before treatment (P <0.05), but still higher than that of the control group (P <0.05). Conclusion: The level of ANG in serum of patients with NPC is increased, and the degree of its elevation is related to the progress of the tumor.