环境污染的加剧,导致过敏反应相应地增加,由此引伸对第2代组胺H_1受体阻断药开发的日趋重视,新药不断上市,其作用强而持久,对中枢和植物神经系统的不良反应甚微,但部分药物对心脏的毒性却日益突出,过量或同时并用肝酶P450抑制剂偶可出现严重的心律失常(尖端扭转型室性心动过速)。为此,对其产生心脏毒性原因及合理应用问题进行探讨,以寻求应用时的防范措施。 Increased environmental pollution, resulting in an increase in allergic reactions, the extension of the second generation of histamine H_1 receptor blocker development of the growing emphasis on new drugs continue to market, its role is strong and lasting, to the central and autonomic nervous system Reactions to very little, but some of the drugs on the heart of the increasingly acute toxicity, excessive or concurrent with liver enzymes P450 even occasional severe arrhythmia (Torsades de pointes). To this end, its causes of cardiac toxicity and rational use of the issue to explore in order to seek the application of preventive measures.